AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on October 9, 2007
doi: 10.3174/ajnr.A0781
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American Journal of Neuroradiology 29:18-22, January 2008
© 2008 American Society of Neuroradiology

Pathology Review

Neuropathology for the Neuroradiologist: Plaques and Tangles

F.J. Wippold, IIa,b,c,d, N. Cairnsd,e,f, K. Voa,b, D.M. Holtzmand,f,g and J.C. Morrisd,g

a Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Mo
b Department of Radiology, Barnes-Jewish Hospital South, St. Louis, Mo
c Department of Radiology/Nuclear Medicine, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md
d Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, Mo
e Neuropathology Division, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Mo
f Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Mo
g Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, Mo

Please address correspondence to: Franz J. Wippold II, MD, Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University Medical Center, 510 South Kingshighway Blvd, St. Louis, MO 63110; e-mail: wippoldf{at}wustl.edu

SUMMARY: Histologically identified intracellular and extracellular inclusions and structures often provide a tissue diagnosis of a specific disease process. Moreover, these deposits may provide clues about the pathogenesis of the disease in which they are found. Two distinctive structures seen within the brains of patients clinically diagnosed with dementia of the Alzheimer type are extracellular plaques and intracellular neurofibrillary tangles. The purpose of this report is to review the significance of plaques and neurofibrillary tangles in the context of Alzheimer disease.






Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X