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AJNR - American Journal of Neuroradiology

Published ahead of print on September 10, 2008
doi: 10.3174/ajnr.A1204

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American Journal of Neuroradiology 29:1878-1879, November-December 2008
© 2008 American Society of Neuroradiology

Case Report
BRAIN

Primary Sjögren Syndrome with Tumefactive Central Nervous System Involvement

J. Sanahuja^a, S. Ordoñez-Palau^b, R. Begué^c, L. Brieva^a and D. Boquet^b

^a Department of Neurology, Hospital Universitari Arnau de Vilanova-IRBLleida, Lleida, Spain
^b Department of Rheumatology, Hospital Universitari Arnau de Vilanova-IRBLleida, Lleida, Spain
^c Department of Radiology-Institut de Diagnòstic per la Imatge, Hospital Universitari Arnau de Vilanova-IRBLleida, Lleida, Spain

Please address correspondence to Jordi Sanahuja, MD, Department of Neurology, Hospital Universitari Arnau de Vilanova, Av. Alcalde Rovira Roure 80, 25006 Lleida, Spain; e-mail: jsanahuja{at}comll.cat

SUMMARY: Brain MR imaging abnormalities in primary Sjögren syndrome (pSS) are generally discrete white matter lesions. We describe a 50-year-old woman with recurrent neurologic deficits. MR imaging revealed a large brain lesion. A diagnosis of pSS was made on the basis of clinical features, positive anti-Ro and anti-La antibodies, abnormal Schirmer test findings, and salivary gland scintigraphy. The patient was treated with oral prednisone with good response. Large tumefactive brain lesions are a complication of pSS.