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AJNR - American Journal of Neuroradiology

Published ahead of print on August 21, 2008
doi: 10.3174/ajnr.A1272

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American Journal of Neuroradiology 29:1976-1982, November-December 2008
© 2008 American Society of Neuroradiology

SPINE

Diffusion Tensor MR Imaging in Chronic Spinal Cord Injury

B.M. Ellingson^a, J.L. Ulmer^b, S.N. Kurpad^c and B.D. Schmit^a

^a Department of Biomedical Engineering, Marquette University, Milwaukee, Wis
^b Department of Radiology, Medical College of Wisconsin, Milwaukee, Wis
^c Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wis

Please address correspondence to Brian D. Schmit, PhD, Marquette University, Department of Biomedical Engineering, PO Box 1881, Milwaukee, WI 53201-1881; e-mail: brian.schmit{at}marquette.edu

BACKGROUND AND PURPOSE: Diffusion tensor MR imaging is emerging as an important tool for displaying anatomic changes in the brain after injury or disease but has been less widely applied to disorders of the spinal cord. The aim of this study was to characterize the diffusion properties of the entire human spinal cord in vivo during the chronic stages of spinal cord injury (SCI). These data provide insight into the structural changes that occur as a result of long-term recovery from spinal trauma.

MATERIALS AND METHODS: Thirteen neurologically intact subjects and 10 subjects with chronic SCI (>4 years postinjury) were enrolled in this study. A single-shot twice-refocused spin-echo diffusion-weighted echo-planar imaging pulse sequence was used to obtain axial images throughout the entire spinal cord (C1-L1) in <60 minutes.

RESULTS: Despite heterogeneity in SCI lesion severity and location, diffusion characteristics of the chronic lesion were significantly elevated compared with those of uninjured controls. Fractional anisotropy was significantly lower at the chronic lesion and appeared dependent on the completeness of the injury. Conversely, mean diffusivity measurements in the upper cervical spinal cord in subjects with SCI were significantly lower than those in controls. These trends suggest that the entire neuraxis may be affected by long-term recovery from spinal trauma.

CONCLUSION: These results suggest that diffusion tensor imaging may be useful in the assessment of SCI recovery.