AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on November 16, 2007
doi: 10.3174/ajnr.A0864
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American Journal of Neuroradiology 29:229-234, February 2008
© 2008 American Society of Neuroradiology

Review Article

Noninvasive Molecular Neuroimaging Using Reporter Genes: Part I, Principles Revisited

T.F. Massouda,b, A. Singha and S.S. Gambhirb,c

a From the Department of Radiology, Section of Neuroradiology, University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital, Cambridge, UK
b Molecular Imaging Program at Stanford, Bio-X Program, Stanford University School of Medicine, Stanford, Calif
c Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, Stanford, Calif

Please address correspondence to Tarik F. Massoud, MD, PhD, Department of Radiology, Section of Neuroradiology, University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital, Box 219, Level 5, Hills Rd, Cambridge CB2 2QQ, United Kingdom; e-mail: tfm23{at}radiol.cam.ac.uk

SUMMARY:In this first article, we review the basic principles of using reporter genes for molecular imaging of the brain in living subjects. This approach is emerging as a valuable tool for monitoring gene expression in diverse applications in laboratory animals, including the study of gene-targeted and trafficking cells, gene therapies, transgenic animals, and more complex molecular interactions within the central nervous system. Further development of more sensitive and selective reporters, combined with improvements in detection technology, will consolidate the position of in vivo reporter gene imaging as a versatile method for greater understanding of intracellular biologic processes and underlying molecular neuropathology and will potentially establish a future role in the clinical management of patients with neurologic diseases.




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T.F. Massoud, A. Singh, and S.S. Gambhir
Noninvasive Molecular Neuroimaging Using Reporter Genes: Part II, Experimental, Current, and Future Applications
AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 409 - 418.
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Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X