Advanced

AJNR - American Journal of Neuroradiology

Published ahead of print on February 13, 2008
doi: 10.3174/ajnr.A0963

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A0963v1 29/3/419    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Henson, J.W. Articles by Harris, G.J. PubMed PubMed Citation Articles by Henson, J.W. Articles by Harris, G.J.

American Journal of Neuroradiology 29:419-424, March 2008
© 2008 American Society of Neuroradiology

Review Article

Brain Tumor Imaging in Clinical Trials

J.W. Henson^a,b,c,d,e,f, S. Ulmer^a and G.J. Harris^c,d,f

^a Stephen E. and Catherine Pappas Brain Tumor Imaging Research Program, Massachusetts General Hospital, Boston, Mass
^b Division of Neuroradiology, Massachusetts General Hospital, Boston, Mass
^c 3D Imaging Service, Massachusetts General Hospital, Boston, Mass
^d Department of Radiology, Massachusetts General Hospital, Boston, Mass
^e Neurology Service, Massachusetts General Hospital, Boston, Mass
^f Harvard Medical School, Boston, Mass

Please address correspondence to John W. Henson, MD, Stephen E. and Catherine Pappas Brain Tumor Imaging Research Program, Massachusetts General Hospital, 55 Fruit St, Yawkey Nine East, Boston, MA 02114; e-mail: henson{at}helix.mgh.harvard.edu

SUMMARY: There are substantial challenges in the radiologic evaluation of tumor size during clinical trials, and it is important for neuroradiologists to have a firm understanding of these issues. This review will examine measurement approaches, response criteria, selection of lesions for measurement, technical imaging considerations, interval between tumor measurements and response confirmation, and validity of imaging as a measure of efficacy.