Advanced

AJNR - American Journal of Neuroradiology

Published ahead of print on February 22, 2008
doi: 10.3174/ajnr.A0949

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A0949v1 29/5/944    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Karas, G. Articles by Barkhof, F. PubMed PubMed Citation Articles by Karas, G. Articles by Barkhof, F.

American Journal of Neuroradiology 29:944-949, May 2008
© 2008 American Society of Neuroradiology

BRAIN

Amnestic Mild Cognitive Impairment: Structural MR Imaging Findings Predictive of Conversion to Alzheimer Disease

G. Karas^a,b,c, J. Sluimer^a,b,c, R. Goekoop^b,c, W. van der Flier^c, S.A.R.B. Rombouts^f,g,h, H. Vrenken^a,b, P. Scheltens^c,d, N. Fox^e and F. Barkhof^a,b,c

^a Department of Diagnostic Radiology, VU University Medical Center, Amsterdam, the Netherlands
^b Image Analysis Center, VU University Medical Center, Amsterdam, the Netherlands
^c Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
^d Department of Clinical Neurology, VU University Medical Center, Amsterdam, the Netherlands
^e Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, London, UK
^f Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center and Leiden Institute for Brain and Cognition, Leiden, the Netherlands
^g Department of Psychology, Leiden University, Leiden, the Netherlands
^h Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands

Please address correspondence to Giorgos Karas, MD, Department of Diagnostic Radiology, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands; e-mail: GB.Karas{at}vumc.nl

BACKGROUND AND PURPOSE: Mild cognitive impairment (MCI) is considered by many to be a prodromal phase of Alzheimer disease (AD). We used voxel-based morphometry (VBM) to find out whether structural differences on MR imaging could offer insight into the development of clinical AD in patients with amnestic MCI at 3-year follow-up.

MATERIALS AND METHODS: Twenty-four amnestic patients with MCI were included. After 3 years, 46% had progressed to AD (n = 11; age, 72.7 ± 4.8 years; women/men, 8/3). For 13 patients (age, 72.4 ± 8.6 years; women/men, 10/3), the diagnosis remained MCI. Baseline MR imaging at 1.5T included a coronal heavily T1-weighted 3D gradient-echo sequence. Localized gray matter differences were assessed with VBM.

RESULTS: The converters had less gray matter volume in medial (including the hippocampus) and lateral temporal lobe, parietal lobe, and lateral temporal lobe structures. After correction for age, sex, total gray matter volume, and neuropsychological evaluation, left-sided atrophy remained statistically significant. Specifically, converters had more left parietal atrophy (angular gyrus and inferior parietal lobule) and left lateral temporal lobe atrophy (superior and middle temporal gyrus) than stable patients with MCI.

CONCLUSION: By studying 2 MCI populations, converters versus nonconverters, we found atrophy beyond the medial temporal lobe to be characteristic of patients with MCI who will progress to dementia. Atrophy of structures such as the left lateral temporal lobe and left parietal cortex may independently predict conversion.