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AJNR - American Journal of Neuroradiology

Published ahead of print on November 27, 2008
doi: 10.3174/ajnr.A1400

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American Journal of Neuroradiology 30:19-30, January 2009
© 2009 American Society of Neuroradiology

Physics Review

Susceptibility-Weighted Imaging: Technical Aspects and Clinical Applications, Part 1

E.M. Haacke^a,b, S. Mittal^c,d, Z. Wu^e, J. Neelavalli^b and Y.-C.N. Cheng^a,b

^a Department of Radiology, Wayne State University, Detroit, Mich
^b Department of Biomedical Engineering, Wayne State University, Detroit, Mich
^c Department of Neurosurgery, Wayne State University, Detroit, Mich
^d Karmanos Cancer Institute, Detroit, Mich
^e Department of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada

Please address correspondence to E. Mark Haacke, PhD, Wayne State University, Detroit, MI; e-mail: nmrimaging{at}aol.com

SUMMARY: Susceptibility-weighted imaging (SWI) is a new neuroimaging technique, which uses tissue magnetic susceptibility differences to generate a unique contrast, different from that of spin density, T1, T2, and T2*. In this review (the first of 2 parts), we present the technical background for SWI. We discuss the concept of gradient-echo images and how we can measure local changes in susceptibility. Armed with this material, we introduce the steps required to transform the original magnitude and phase images into SWI data. The use of SWI filtered phase as a means to visualize and potentially quantify iron in the brain is presented. Advice for the correct interpretation of SWI data is discussed, and a set of recommended sequence parameters for different field strengths is given.

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