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AJNR - American Journal of Neuroradiology

Published ahead of print on December 18, 2008
doi: 10.3174/ajnr.A1239

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American Journal of Neuroradiology 30:575-577, March 2009
© 2009 American Society of Neuroradiology

Technical Note
BRAIN

Spin-Echo Echo-Planar Perfusion MR Imaging in the Differential Diagnosis of Solitary Enhancing Brain Lesions: Distinguishing Solitary Metastases from Primary Glioma

G.S. Young^a and K. Setayesh^a

^a From the Department of Radiology of Brigham and Women's Hospital, Harvard Medical School, Boston, Mass

Please address correspondence to Geoffrey S. Young, MD, Brigham and Women's Hospital, Radiology Department, 75 Francis St, Boston, MA 02115; e-mail: GSYOUNG{at}PARTNERS.ORG

SUMMARY: Unlike the more widely reported gradient-echo echo-planar perfusion-weighted imaging (EPI-PWI) technique, spin-echo (SE) EPI relative cerebral blood volume maps select for blood volume in microvessels <8 µm in diameter. This first report of SE-EPI PWI for distinguishing brain metastasis from high-grade glioma demonstrated 88% sensitivity and 72% specificity in 83 patients. We discuss differences in microvessel architecture between high-grade glioma and brain metastasis that may explain the surprising success of SE-EPI in this application and may deserve further investigation.