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AJNR - American Journal of Neuroradiology

Published ahead of print on December 26, 2008
doi: 10.3174/ajnr.A1402

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American Journal of Neuroradiology 30:578-580, March 2009
© 2009 American Society of Neuroradiology

Technical Note
BRAIN

Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease

J.B. Brewer^a, S. Magda^b, C. Airriess^b and M.E. Smith^b

^a Department of Radiology and Neurosciences, University of California, San Diego, San Diego, Calif
^b Department of CorTechs Labs, La Jolla, Calif

Please address correspondence to James B. Brewer, MD, PhD, Human Memory Laboratory, University of California, San Diego, 9500 Gilman Dr, MC 0949, La Jolla, CA 92093; e-mail: jbrewer{at}ucsd.edu

SUMMARY: Volumetric analysis of structural MR images of the brain may provide quantitative evidence of neurodegeneration and help identify patients at risk for rapid clinical deterioration. This note describes tests of a fully automated MR imaging postprocessing system for volumetric analysis of structures (such as the hippocampus) known to be affected in early Alzheimer disease (AD). The system yielded results that correlated highly with independent computer-aided manual segmentation and were sensitive to the anatomic atrophy characteristic of mild AD.