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AJNR - American Journal of Neuroradiology

Published ahead of print on October 22, 2008
doi: 10.3174/ajnr.A1321

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American Journal of Neuroradiology 30:586-587, March 2009
© 2009 American Society of Neuroradiology

Case Report
BRAIN

Posterior Reversible Encephalopathy Syndrome after Intravenous Caffeine for Post–Lumbar Puncture Headaches

G.A. Ortiz^a, N.A. Bianchi^a, M.P. Tiede^a and R.G. Bhatia^b

^a Department of Neurology, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, Fla
^b Department of Radiology, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, Fla

Please address correspondence to Gustavo A. Ortiz, MD, 1150 NW 14th St, Suite 603, Miami, FL 33136; e-mail: gortiz2{at}med.miami.edu

SUMMARY: A 33-year-old woman developed severe post–lumbar puncture headaches in the course of work-up for multiple sclerosis. Immediately after receiving treatment with intravenous caffeine, she became blind and experienced a generalized tonic-clonic seizure. Brain MR imaging then showed vasogenic parieto-occipital edema. She recovered clinically and radiologically within 72 hours. After 1 year of follow-up, there was no recurrence of symptoms or radiologic changes.