Advanced

AJNR - American Journal of Neuroradiology

Published ahead of print on March 6, 2009
doi: 10.3174/ajnr.A1487

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1487v1 ajnr.A1487v2 30/4/662    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Konstas, A.A. Articles by Lev, M.H. Search for Related Content PubMed PubMed Citation Articles by Konstas, A.A. Articles by Lev, M.H.

American Journal of Neuroradiology 30:662-668, April 2009
© 2009 American Society of Neuroradiology

Physics Review

Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 1: Theoretic Basis

A.A. Konstas^a, G.V. Goldmakher^a, T.-Y. Lee^b and M.H. Lev^a

^a Department of Radiology, Massachusetts General Hospital, Boston, Mass
^b Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada

Please address correspondence to Angelos A. Konstas, MD, Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114; e-mail: akonstas{at}partners.org

SUMMARY: CT perfusion (CTP) is a functional imaging technique that provides important information about capillary-level hemodynamics of the brain parenchyma and is a natural complement to the strengths of unenhanced CT and CT angiography in the evaluation of acute stroke, vasospasm, and other neurovascular disorders. CTP is critical in determining the extent of irreversibly infarcted brain tissue (infarct "core") and the severely ischemic but potentially salvageable tissue ("penumbra"). This is achieved by generating parametric maps of cerebral blood flow, cerebral blood volume, and mean transit time.

This article has been cited by other articles:

				M. Wintermark and M.H. Lev FDA Investigates the Safety of Brain Perfusion CT AJNR Am. J. Neuroradiol., January 1, 2010; 31(1): 2 - 3. [Full Text] [PDF]

				V. A. Nagar, A. M. McKinney, A. T. Karagulle, and C. L. Truwit Reperfusion Phenomenon Masking Acute and Subacute Infarcts at Dynamic Perfusion CT: Confirmation by Fusion of CT and Diffusion-Weighted MR Images Am. J. Roentgenol., December 1, 2009; 193(6): 1629 - 1638. [Abstract] [Full Text] [PDF]

				A.A. Konstas, G.V. Goldmakher, T.-Y. Lee, and M.H. Lev Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 2: Technical Implementations AJNR Am. J. Neuroradiol., May 1, 2009; 30(5): 885 - 892. [Abstract] [Full Text] [PDF]