AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on March 19, 2009
doi: 10.3174/ajnr.A1492
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American Journal of Neuroradiology 30:885-892, May 2009
© 2009 American Society of Neuroradiology

Physics Review

Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 2: Technical Implementations

A.A. Konstasa, G.V. Goldmakhera, T.-Y. Leeb and M.H. Leva

a Department of Radiology, Massachusetts General Hospital, Boston, Mass
b Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada

Please address correspondence to Angelos A. Konstas, MD, Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114; e-mail: akonstas{at}partners.org

SUMMARY: CT perfusion (CTP) is a functional imaging technique that provides important information about capillary-level hemodynamics of the brain parenchyma and is a natural complement to the strengths of unenhanced CT and CT angiography in the evaluation of acute stroke, vasospasm, and other neurovascular disorders. CTP is critical in determining the extent of irreversibly infarcted brain tissue (infarct "core") and the severely ischemic but potentially salvageable tissue ("penumbra"). This is achieved by generating parametric maps of cerebral blood flow, cerebral blood volume, and mean transit time.




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Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X