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AJNR - American Journal of Neuroradiology

Published ahead of print on March 19, 2009
doi: 10.3174/ajnr.A1513

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American Journal of Neuroradiology 30:917-922, May 2009
© 2009 American Society of Neuroradiology

BRAIN

C-Arm CT Measurement of Cerebral Blood Volume: An Experimental Study in Canines

A.S. Ahmed^a, M. Zellerhoff^b, C.M. Strother^a, K.A. Pulfer^a, T. Redel^b, Y. Deuerling-Zheng^b, K. Royalty^b, D. Consigny^a and D.B. Niemann^a

^a University of Wisconsin Hospitals and Clinics, Madison, Wis
^b Siemens AG, Forchheim, Germany

Please address correspondence to Charles M. Strother, MD, 600 Highland Ave, Madison, WI 53792; e-mail: CStrother{at}uwhealth.org

BACKGROUND AND PURPOSE: Cerebral blood volume (CBV) is an important parameter in estimating the viability of brain tissue following an ischemic event. We tested the hypothesis that C-arm CT measurements of CBV would correlate well with those made with perfusion CT (PCT).

MATERIALS AND METHODS: CBV was measured in 12 canines by using PCT and C-arm CT. Two measurements with each technique were made on each animal; a different injection protocol was used for each of these techniques. PCT was performed by using a 64-section V-scanner. C-arm CT was performed by using a biplane Artis dBA system. PCT images were transferred to a commercially available workstation for postprocessing and analysis; C-arm CT images were transferred to a commercially available workstation for postprocessing and analysis by using prototype software. From each animal, 2 sections from each technique were selected for analysis.

RESULTS: There was good agreement of both the color maps and absolute numbers between the 2 techniques. The maximum and mean deviations of values between the 2 techniques for the first 5 animals were 30.20% and 7.82%; for the second 7 animals, these values were 26.79% and 7.40%. The maximum and mean deviations between the 2 C-arm CT studies performed on the first 5 animals were 33.15% and 12.24%; for the second 7 animals, these values were 41.15% and 10.89%.

CONCLUSIONS: In these healthy animals, measurement of CBV with C-arm CT compared well with measurements made with PCT.