AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on April 8, 2009
doi: 10.3174/ajnr.A1557
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American Journal of Neuroradiology 30:1096-1101, June-July 2009
© 2009 American Society of Neuroradiology

Research Perspectives

Challenges of Using MR Spectroscopy to Detect Neural Progenitor Cells In Vivo

Z. Donga,b, W. Dreherc,d, D. Leibfritzc,d and B.S. Petersona,b

a Department of Psychiatry, Columbia University, New York, NY
b MRI Unit, New York State Psychiatric Institute, New York, NY
c Fachbereich 2, Universität Bremen, Bremen, Germany
d Center for Advanced Imaging, Bremen, Germany

Please address correspondence to Zhengchao Dong, PhD, Department of Psychiatry, Columbia University and New York State Psychiatric Institute 1051 Riverside Dr, Unit 74, New York, N.Y. 10032; e-mail: zd2109{at}columbia.edu

SUMMARY: A recent report of detection of neural progenitor cells (NPCs) in living human brain by using in vivo proton MR spectroscopy (1H-MR spectroscopy) has sparked great excitement in the field of biomedicine because of its potential influence and utility in clinical neuroscience research. On the other hand, the method used and the findings described in the report also caused heated debate and controversy. In this article, we will briefly detail the reasons for the debate and controversy from the point of view of the in vivo 1H-MR spectroscopy methodology and will propose some technical strategies in both data acquisition and data processing to improve the feasibility of detecting NPCs in future studies by using in vivo 1H-MR spectroscopy.






Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X