AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on July 17, 2009
doi: 10.3174/ajnr.A1590
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American Journal of Neuroradiology 30:1293-1301, August 2009
© 2009 American Society of Neuroradiology

Research Perspectives

Uses of Nanoparticles for Central Nervous System Imaging and Therapy

J.M. Provenzalea,b and G.A. Silvac

a Department of Radiology, Duke University Medical Center, Durham, NC
b Departments of Radiology, Oncology and Biomedical Engineering, Emory University School of Medicine, Atlanta, Ga
c Departments of Bioengineering and Ophthalmology, University of California, San Diego; San Diego, Calif

Please address correspondence to James M. Provenzale, MD, Duke University Medical Center, Neuroradiology Division, Department of Radiology DUMC-3808, Durham, NC 27710-3808; e-mail: prove001{at}mc.duke.edu

SUMMARY: Applications of nanotechnology to medicine are leading to novel means of imaging living systems and of delivering therapy. Much nanotechnology research is focused on methods for imaging central nervous system functions and disease states. In this review, the principles of nanoparticle design and function are discussed with specific emphasis on applications to neuroradiology. In addition to innovative forms of imaging, this review describes therapeutic uses of nanoparticles, such as drug delivery systems, neuroprotection devices, and methods for tissue regeneration.






Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X