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AJNR - American Journal of Neuroradiology

Published ahead of print on August 20, 2009
doi: 10.3174/ajnr.A1617

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American Journal of Neuroradiology 30:1496-1501, September 2009
© 2009 American Society of Neuroradiology

INTERVENTIONAL

Cerecyte versus Platinum Coils in the Treatment of Intracranial Aneurysms: Packing Attenuation and Clinical and Angiographic Midterm Results

I. Linfante^a, M.J. DeLeo, III^b, M.J. Gounis^b,c, C.S. Brooks^b and A.K. Wakhloo^b,c

^aFrom the Baptist Cardiac and Vascular Institute (I.L.), Miami, Fla
^bDepartments of Radiology (M.J.D.III, M.J.G., C.S.B., A.K.W.)
^cDivision of Biomedical Imaging and Bioengineering, (M.J.G., A.K.W.), University of Massachusetts, Worcester, Mass.

Please address correspondence to Ajay K. Wakhloo, MD, PhD, Division of Neuroimaging and Intervention, Department of Radiology, Neurology and Neurosurgery, University of Massachusetts, 55 Lake Ave N, Worcester, MA 01655; e-mail: wakhlooa{at}ummhc.org

BACKGROUND AND PURPOSE: As modifications are made to coils, monitoring the safety profile, ability to achieve high packing attenuation, and durability of occlusion as compared to the standard bare platinum coils is of paramount importance. We compared packing attenuation, initial occlusion, and recanalization rates between Cerecyte and bare platinum coils in the treatment of ruptured and unruptured cerebral aneurysms.

MATERIALS AND METHODS: We compared 63 patients (67 aneurysms) treated with Cerecyte coils with 65 patients (70 aneurysms) treated by using bare platinum coils. Results were classified by the Raymond score. Clinical outcomes were assessed by using a modified Rankin Scale. Angiographic and clinical follow-ups were performed routinely at 6 and 12 months after the intervention.

RESULTS: In the Cerecyte group, complete occlusion of the aneurysm (grade 1) was accomplished in 49% (33/67), a small residual neck (grade 2) was seen in 21% (14/67), and dome filling (grade 3) was seen in 30% (20/67). In the platinum group, 41% (29/70) were grade 1, 39% (27/70) were grade 2, and 20% (14/70) were grade 3 immediately postembolization. Mean packing attenuation was 43 ± 28% in the Cerecyte group and 40 ± 23% in the bare platinum group (P = .68). Twelve-month follow-up data were available for 54% (36/67) of the Cerecyte population and 43% (30/70) of the bare platinum population. There were 5 cases of neck recanalization (11%) in the Cerecyte group and 11 cases (23%) in the bare platinum group (P = .17). No rebleeds were noted in the follow-up period.

CONCLUSIONS: Cerecyte coils have a satisfactory safety profile. We were able to achieve high packing attenuations and initial occlusion rates similar to those obtainable with platinum coils.

This article has been cited by other articles:

				M. J. Gounis, M. J. De Leo III, and A. K. Wakhloo Advances in Interventional Neuroradiology Stroke, February 1, 2010; 41(2): e81 - e87. [Full Text] [PDF]