Resting-State Functional MRI: Everything That Nonexperts Have Always Wanted to Know
Abstract
SUMMARY: Resting-state fMRI was first described by Biswal et al in 1995 and has since then been widely used in both healthy subjects and patients with various neurologic, neurosurgical, and psychiatric disorders. As opposed to paradigm- or task-based functional MR imaging, resting-state fMRI does not require subjects to perform any specific task. The low-frequency oscillations of the resting-state fMRI signal have been shown to relate to the spontaneous neural activity. There are many ways to analyze resting-state fMRI data. In this review article, we will briefly describe a few of these and highlight the advantages and limitations of each. This description is to facilitate the adoption and use of resting-state fMRI in the clinical setting, helping neuroradiologists become familiar with these techniques and applying them for the care of patients with neurologic and psychiatric diseases.
ABBREVIATIONS:
- ALFF
- Amplitude of Low Frequency Fluctuations
- BOLD
- blood oxygen level–dependent
- FCD
- functional connectivity density
- ICA
- independent component analysis
- ReHo
- regional homogeneity
- rs-fMRI
- resting-state fMRI
- © 2018 by American Journal of Neuroradiology
Indicates open access to non-subscribers at www.ajnr.org
In this issue
Jump to section
Related Articles
- No related articles found.
Cited By...
- A Comprehensive and Broad Approach to Resting-State Functional Connectivity in Adult Patients with Mild Traumatic Brain Injury
- Co-representation of Functional Brain Networks Is Shaped by Cortical Myeloarchitecture and Reveals Individual Behavioral Ability
- A Cross-Sectional and Longitudinal Integrated Study on Brain Functional Changes in a Neuropathic Pain Rat Model
- Corticospinal excitability at rest outside of a task does not differ from task intertrial intervals in healthy adults
- Priming transcranial direct current stimulation for improving hemiparetic upper limb in patients with subacute stroke: study protocol for a randomised controlled trial
- Right-to-Left Shunt-associated Brain Functional Changes in Migraine: Evidences from a Resting-state FMRI Study
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: a systematic review
- Connectivity Regression
- Genetic influences on the intrinsic and extrinsic functional organizations of the cerebral cortex
- N-acetyl Cysteine attenuates intrinsic functional connectivity, but not neural alcohol cue reactivity, in treatment-seeking individuals with alcohol use disorder
- Prosocial Decision-Making and Human Brain: A Graph Theory Analysis on Resting-State Functional Magnetic Resonance Image
- Seed-based morphometry of nodes in the default mode network among patients with Alzheimers disease in Klang Valley, Malaysia
- Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure
- Altered regional homogeneity and its association with cognitive function in adolescents with borderline personality disorder
- Assessing The Repeatability of Multi-Frequency Multi-Layer Brain Network Topologies Across Alternative Researchers Choice Paths
- Novel inductively-coupled ear-bars (ICEs) for fMRI signal enhancement in rat entorhinal cortex
- Effects of a single-dose methylphenidate challenge on resting-state functional connectivity in stimulant-treatment naive children and adults with ADHD
- A novel rhesus macaque model of Huntingtons disease recapitulates key neuropathological changes along with progressive motor and cognitive decline
- Chemogenetic activation of Locus Coeruleus Noradrenergic Neurons Modulates the Default Mode Network
- Resting-state functional reorganisation in Alzheimers disease and amnestic mild cognitive impairment: protocol for a systematic review and meta-analysis
- Resting-State Functional MRI for Determining Language Lateralization in Children with Drug-Resistant Epilepsy
- Sex Differences in Brain Structures and Functional Connectivity among Patients with Bipolar I Disorder
- Time-varying Dynamic Network Model For Dynamic Resting State Functional Connectivity in fMRI and MEG imaging
- Functional network dynamics in progressive multiple sclerosis
- Common variants contribute to intrinsic human brain functional networks
- Structural and functional brain parameters related to cognitive performance across development: Replication and extension of the parieto-frontal integration theory in a single sample
- Default mode network anatomy and function is linked to pediatric concussion recovery
- Network-wide abnormalities explain memory variability in hippocampal amnesia
- Interaction of Developmental Venous Anomalies with Resting-State Functional MRI Measures
This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.
- Qian Sun, Guan-Qun Chen, Xi-Bin Wang, Ying Yu, Yu-Chuan Hu, Lin-Feng Yan, Xin Zhang, Yang Yang, Jin Zhang, Bin Liu, Cong-Cong Wang, Yi Ma, Wen Wang, Ying Han, Guang-Bin CuiFrontiers in Neuroanatomy 2018 12
- Angela Guadagno, Min Su Kang, Gabriel A. Devenyi, Axel P. Mathieu, Pedro Rosa-Neto, Mallar Chakravarty, Claire-Dominique WalkerBrain Structure and Function 2018 223 8
- Erin E. O'Connor, Thomas A. ZeffiroFrontiers in Neurology 2019 10
- Ritika Jain, Angarai Ganesan RamakrishnanFrontiers in Neuroscience 2020 14
- Zheng Wang, Yan Wang, John A. Sweeney, Qiyong Gong, Su Lui, Matthew W. MosconiFrontiers in Integrative Neuroscience 2019 13
- Georgios PD Argyropoulos, Clare Loane, Adriana Roca-Fernandez, Carmen Lage-Martinez, Oana Gurau, Sarosh R Irani, Christopher R ButlereLife 2019 8
- Urvakhsh Meherwan Mehta, Ferose Azeez Ibrahim, Manu S. Sharma, Ganesan Venkatasubramanian, Jagadisha Thirthalli, Rose Dawn Bharath, Nicolas R. Bolo, Bangalore N. Gangadhar, Matcheri S. KeshavanSchizophrenia Research 2021 237
- Lv Han, Zeng Na, Liu Chunli, Chen Yuchen, Zhao Pengfei, Wang Hao, Cheng Xu, Zhang Peng, Wang Zheng, Yang Zhenghan, Gong Shusheng, Wang ZhenchangFrontiers in Neuroscience 2019 13
- Antonio Carotenuto, Sirio Cocozza, Mario Quarantelli, Giorgio Arcara, Roberta Lanzillo, Vincenzo Brescia Morra, Ilaria Cerillo, Enrico Tedeschi, Giuseppe Orefice, Valentina Bambini, Arturo Brunetti, Rosa IodiceBrain and Language 2018 185
- Li Zhou, Guiqian Liu, Hong Luo, Huabing Li, Yating Peng, Dandan Zong, Ruoyun OuyangFrontiers in Neurology 2020 11