American Journal of Neuroradiology, Vol 4, Issue 3 299-301, Copyright © 1983 by American Society of Neuroradiology
ARTICLES |
Iohexol in lumbar myelography: preliminary results from an open, noncomparative multicenter clinical study
OP Eldevik, P Nakstad, BE Kendall and T Hindmarsh
This is a preliminary report of the first clinical trials using iohexol as a contrast agent in lumbar myelography. The study was noncomparative and involved 82 adult patients in four centers. Iohexol doses of 10-15 ml (180 mg I/ml) were administered and clinical and laboratory tests were performed before and at intervals during 48 hr after myelography. Side effects were noted in 29 (35%) of 82 patients. Spinal repuncture 6 or 24 hr after myelography was performed in 51 patients. No significant increases in cerebrospinal fluid parameters were seen. No seizures or spikes on electroencephalography were seen.