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American Journal of Neuroradiology, Vol 4, Issue 3 317-318, Copyright © 1983 by American Society of Neuroradiology

ARTICLES

Iotrol, a new myelographic agent: 1. Radiography, CT, CSF clearance, and brain penetration

CW Kerber, M Sovak, RS Ranganathan and CB Heilman

Four new myelographic agents, metrizamide, iopamidol, iohexol, and iotrol, were studied in the subarachnoid space of cynomolgus monkeys. Plain films and computed tomographic scans documented the transport of each material throughout the space and into the brain. At the concentration used (300 mg I/ml), all gave good radiopacity for myelography and delineation of the cerebral subarachnoid space. All four cleared similarly from the ventricular system. Metrizamide, however, penetrated the brain in greater degree and persisted longer than the other three agents. Next in persistence was iopamidol and least, and both statistically equal, iotrol and iohexol.




Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X