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American Journal of Neuroradiology, Vol 5, Issue 4 413-417, Copyright © 1984 by American Society of Neuroradiology

ARTICLES

Relative uptake of low- and high-osmolality contrast media in CT of brain tumors

JR Fike, CE Cann, D Norman, JM Turrel, RA LeCouteur, CM Pflugfelder and JK Borcich

The magnitude and time course of contrast enhancement in spontaneous canine brain tumors was determined for two contrast agents: meglumine iothalamate and sodium meglumine ioxaglate. Tumor enhancement during contrast infusion and at 5, 10, 15, 30, and 45 min was measured using quantitative computed tomography. Blood iodine was measured using x-ray fluorescence. Peak contrast enhancement occurred during the infusion, and the magnitude was the same for both agents. Per gram of iodine infused, blood iodine was 12.4% higher with ioxaglate than iothalamate. The monoionic dimer ioxaglate is as effective as iothalamate for enhancement of canine brain tumors.




Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X