AJDRAJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 2009;30:1751.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A1623

BRAIN

Ipilimumab-Induced Hypophysitis: MR Imaging Findings

K.J. Carpenter, R.D. Murtagh, H. Lilienfeld, J. Weber and F.R. Murtagh

From the Department of Radiology (K.J.C., R.D.M., F.R.M.), University of South Florida, Tampa, Fla; University Diagnostic Institute (R.D.M., F.R.M,), Tampa, Fla; and Departments of Diagnostic Imaging and Interdisciplinary Oncology (R.D.M., F.R.M.), Endocrinology (H.L.) and Cutaneous Surgery (J.W.), Moffitt Cancer Center and Research Institute, Tampa, Fla.

Please address correspondence to Ryan D. Murtagh, MD, MBA, University Diagnostic Institute, 3301 Alumni Dr, Tampa FL 33629; e-mail: rmurtagh13{at}gmail.com

SUMMARY: Ipilimumab is a promising new immunotherapeutic antineoplastic agent with clinical activity in the treatment of metastatic melanoma and renal cell carcinoma. With advances in immunotherapy, however, a host of new side effects related to the mechanism of action of these drugs has appeared. At our institution, 3 patients presented with hypophysitis, which was attributed to an autoimmune process based on the documented relationship of the drug to other autoimmune phenomena and significant and rapid improvement with discontinuation of the drug and addition of steroids. We present the imaging findings in 3 patients with presumed ipilimumab-induced hypophysitis.






Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X