Abstract
SUMMARY: Resting-state fMRI was first described by Biswal et al in 1995 and has since then been widely used in both healthy subjects and patients with various neurologic, neurosurgical, and psychiatric disorders. As opposed to paradigm- or task-based functional MR imaging, resting-state fMRI does not require subjects to perform any specific task. The low-frequency oscillations of the resting-state fMRI signal have been shown to relate to the spontaneous neural activity. There are many ways to analyze resting-state fMRI data. In this review article, we will briefly describe a few of these and highlight the advantages and limitations of each. This description is to facilitate the adoption and use of resting-state fMRI in the clinical setting, helping neuroradiologists become familiar with these techniques and applying them for the care of patients with neurologic and psychiatric diseases.
ABBREVIATIONS:
- ALFF
- Amplitude of Low Frequency Fluctuations
- BOLD
- blood oxygen level–dependent
- FCD
- functional connectivity density
- ICA
- independent component analysis
- ReHo
- regional homogeneity
- rs-fMRI
- resting-state fMRI
Footnotes
Disclosures: Leanne M. Williams—UNRELATED: Board Membership: PsyberGuide, Comments: member of the Scientific Advisory Board; Grants/Grants Pending: National Institutes of Health*; Payment for Lectures Including Service on Speakers Bureaus: University of Minnesota, Comments: Grand Rounds. Greg Zaharchuk—UNRELATED: Grants/Grants Pending: National Institutes of Health, GE Healthcare. Michael Zeineh—UNRELATED: Grants/Grants Pending: National Institutes of Health, Doris Duke Charitable Foundation, Dana Foundation, Foundation of the ASNR, GE Healthcare*. Tali M. Ball—RELATED: Grant: National Institute of Mental Health, Comments: Salary support was provided by National Institute of Mental Health training grant T32MH019938; UNRELATED: Other: PsyberGuide, Comments: one-time payment to provide content for their Web site. Max Wintermark—UNRELATED: Board Membership: GE NFL Advisory Board. *Money paid to the institution.
Dr Ball is supported by grant T32MH019938 from the National Institute of Mental Health.
The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- © 2018 by American Journal of Neuroradiology
Indicates open access to non-subscribers at www.ajnr.org