Abstract
BACKGROUND AND PURPOSE: A small subset of primary central nervous system lymphomas exhibits high cerebral blood volume, which is indistinguishable from that in glioblastoma on dynamic susceptibility contrast MR imaging. Our study aimed to test whether estimates of combined perfusion and vascular permeability metrics derived from DSC-MR imaging can improve the diagnostic performance in differentiating hypervascular primary central nervous system lymphoma from glioblastoma.
MATERIALS AND METHODS: A total of 119 patients (with 30 primary central nervous system lymphomas and 89 glioblastomas) exhibited hypervascular foci using the reference method of leakage-corrected CBV (reference-normalized CBV). An alternative postprocessing method used the tissue residue function to calculate vascular permeability (extraction fraction), leakage-corrected CBV, cerebral blood flow, and mean transit time. Parameters were compared using Mann-Whitney U tests, and the diagnostic performance to distinguish primary central nervous system lymphoma from glioblastoma was calculated using the area under the curve from the receiver operating characteristic curve and was cross-validated with bootstrapping.
RESULTS: Hypervascular primary central nervous system lymphoma showed similar leakage-corrected normalized CBV and leakage-corrected CBV compared with glioblastoma (P > .05); however, primary central nervous system lymphoma exhibited a significantly higher extraction fraction (P < .001) and CBF (P = .01) and shorter MTT (P < .001) than glioblastoma. The extraction fraction showed the highest diagnostic performance (the area under the receiver operating characteristic curve [AUC], 0.78; 95% confidence interval, 0.69–0.85) for distinguishing hypervascular primary central nervous system lymphoma from glioblastoma, with a significantly higher performance than both CBV (AUC, 0.53–0.59, largest P = .02) and CBF (AUC, 0.72) and MTT (AUC, 0.71).
CONCLUSIONS: Estimation of vascular permeability with DSC-MR imaging further characterizes hypervascular primary central nervous system lymphoma and improves diagnostic performance in glioblastoma differentiation.
ABBREVIATIONS:
- AUC
- area under the receiver operating characteristic curve
- CBVres
- leakage-corrected CBV derived using the proposed residue function–based correction method
- DCE
- dynamic contrast-enhanced
- EF
- extraction fraction
- Ktrans
- contrast agent transfer constant
- nCBVref
- leakage-corrected normalized CBV derived using the reference-correction method
- PCNSL
- primary central nervous system lymphoma
Footnotes
Disclosures: Atle Bjørnerud—UNRELATED: Consultancy: NordicNeuroLab AS, Comments: software development; Patents (Planned, Pending or Issued): Oslo University Hospital, Comments: patent applications relating to perfusion analysis methods*; Royalties: NordicNeuroLab AS, Comments: royalties from patents*; Stock/Stock Options: NordicNeuroLab AS. *Money paid to the institution.
This research was supported by the National Research Foundation of Korea grant funded by the Korean government (Ministry of Science, ICT and Future Planning) (grant number: NRF-2017R1C1B2007258) and by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1720030). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the article.
- © 2018 by American Journal of Neuroradiology
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