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AJNR - American Journal of Neuroradiology

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Classification of Biopsy-Confirmed Brain Tumors Using Single-Voxel MR Spectroscopy

M. Elizabeth Meyerand^,a, J. Marc Pipas^a, Alex Mamourian^a, Tor D. Tosteson^a and Jeffery F. Dunn^a

^a From the Departments of Diagnostic Radiology (M.E.M., A.M., J.F.D.), Community and Family Medicine (T.D.T.), and Hematology and Oncology (J.M.P.), Biomedical NMR Research Lab, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Hanover, NH.

View larger version (18K): [in a new window]   FIG 1. A–D, Representative localized in vivo spectra from a healthy control subject (A), a 36-year-old patient with a low-grade tumor (B), a 21-year-old patient with an anaplastic astrocytoma (C), and a 57-year-old patient with a GBM (D). In all cases the pulse sequence parameters were 2000/272/128 (TR/TE/excitations)

View larger version (13K): [in a new window]   FIG 2. A–F, Graphs show the ratios to water and to creatine for the three tumor types in all patients (n = 27) and control subjects (n = 5): lactate to water ratio (A), choline to water ratio (B), NAA to water ratio (C), choline to creatine ratio (D), lactate to creatine ratio (E), and NAA to creatine ratio (F)

View larger version (16K): [in a new window]   FIG 3. A–D, Simulated spectra generated from the average peak heights and linewidths for each patient in all three tumor groups and in the control group. Average spectra from the control subjects (n = 5) (A), from the patients with low-grade astrocytomas (n = 8) (B), from the patients with anaplastic astrocytomas (n = 6) (C), and from the patients with GBMs (n = 13) (D)