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AJNR - American Journal of Neuroradiology

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Interscanner Variation in Brain MR Lesion Load Measurements in Multiple Sclerosis Using Conventional Spin-Echo, Rapid Relaxation-Enhanced, and Fast-FLAIR Sequences

Massimo Filippi^,a, Maria A. Rocca^a, Claudio Gasperini^a, Maria P. Sormani^a, Stefano Bastianello^a, Mark A. Horsfield^a, Carlo Pozzilli^a and Giancarlo Comi^a

^a From the Neuroimaging Research Unit (M.F., M.A.R., M.P.S.) and Clinical Trials Unit (G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan; Departments of Neurology (C.G., C.P.) and Neuroradiology (S.B.), Università "La Sapienza," Rome; Department of Neurology (C.G.), San Camillo Hospital, Rome; Unit of Clinical Epidemiology and Trials (M.P.S.), Institute for Cancer Research, Genoa, Italy; and Division of Medical Physics (M.A.H.), University of Leicester, Leicester, UK.

View larger version (120K): [in a new window]   FIG 1. Axial RARE moderately T2-weighted images obtained from scanner A (A) (3800/22/1) and scanner B (B) (3800/25/1). Several hyperintense lesions are visible in both the cerebral hemispheres

View larger version (135K): [in a new window]   FIG 2. Axial FLAIR images obtained from scanner A (A) (9999/105/1; TI, 2200) and scanner B (B) (6500/150/2; TI, 2000) at the same anatomic level as in figure 1