Characteristic MR Lesion Pattern and Correlation of T1 and T2 Lesion Volume with Neurologic and Neuropsychological Findings in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)
,
Tarek A. Yousry,a,
Klaus Seelosa,
Michael Mayera,
Roland Brüninga,
Ingo Uttnera,
Martin Dichgansa,
Sylvia Mammia,
Andreas Straubea,
Norbert Maia and
Massimo Filippia
a From the Departments of Neuroradiology (T.A.Y., K.S.), Neurology (M.M., I.U., M.D., A.S., N.M.), and Diagnostic Radiology (R.B.), Klinikum Grosshadern, Ludwig-Maximilian University, Munich, Germany; and the Department of Neurology, Scientific Institute Ospedale San Raffaele, University of Milan, Italy (S.M., M.F.).
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FIG 1. A–D, In the early phase of the disease (subject B3: 35-year-old woman), multiple, small lesions are found in the centrum semiovale (mainly in the frontal lobe) (A). In a later stage (subject B4: 61-year-old woman), confluent lesions are typically found in the white matter of the centrum semiovale (B), the frontal horns and trigones (C), and the internal and external capsule (D)
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FIG 2. A–D, The typical pattern of lesion distribution includes confluent lesions in the external capsule (A: subject B4), the subcortical white matter of the insula (A and B: subject A2), the subcortical frontal white matter (B), and the temporal poles (C: subject A3, and D: subject A8). The orbital part of the frontal lobe is spared (C)
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