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AJNR - American Journal of Neuroradiology

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Magnetization-Transfer Histogram Analysis of the Cervical Cord in Patients with Multiple Sclerosis

Marco Bozzali^a, Maria A. Rocca^a, Giuseppe Iannucci^a, Clodoaldo Pereira^a, Giancarlo Comi^a and Massimo Filippi^,a

^a From the Neuroimaging (M.B., M.A.R., G.I., C.P., M.F.) and Clinical Trials Units (G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Milan, Italy

View larger version (131K): [in a new window]   FIG 1. Axial gradient-echo (TR/TE/excitations = 640/10/2) images of cervical cord at C5 without (A) and with (B) the saturation pulse.

View larger version (91K): [in a new window]   FIG 2. Midsagittal gradient-echo (640/10/2) images of cervical cord without (A) and with (B) saturation pulse. Two lesions are visible.

View larger version (22K): [in a new window]   FIG 3. MTR histograms of cervical cord from controls (black line) and entire MS cohort (gray line). Graph A shows MTR histograms from axial, 5-mm-thick slices, graph B shows MTR histograms from sagittal, 3-mm-thick slices.