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Pallister-Hall Syndrome: Clinical and MR Features

Jeffrey S. KuoGo,a, Sean O. Caseya, Linda Thompsona and Charles L. Truwita

a From the Department of Neuroradiology (J.S.K., S.O.C., L.T., C.L.T.), University of Minnesota, Minneapolis, Minnesota.



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  		FIG 1. Single image from laryngoscopy demonstrates large midline cleft (black arrow) through the epiglottis (white arrows).

FIG 2. Anteroposterior conventional radiograph of left hand shows polydactyly with hypoplastic accessory metacarpal, proximal, and mid phalange between fourth and fifth digits.



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  		FIG 3. Sagittal T1-weighted (580/14/2 [TR/TE/excitations]) MR image demonstrates large sellar and suprasellar mass extending over and through dorsum sella and into pontine cistern. The infundibulum is anteriorly displaced and pituitary (arrow) is compressed. Posterior displacement of pons and midbrain with superior displacement of third ventricle is visible.



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  		FIG 4. A and B, Axial (A) and coronal (B) T2-weighted (2500/90/1) MR images show heterogeneous appearance to tumor with mixed signal intensities equivalent to white and gray matter of remaining normal brain.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X