Diffusion-Negative Stroke: A Report of Two Cases
Paul Y-K. Wanga,
Peter B. Barker
,a,
Robert J. Wityka,
Aziz M. Ulu
a,
Peter C. M. van Zijla and
Norman J. BeauchampJra
a From the Departments of Radiology (P.Y-K.W., P.B.B., A.M.U., P.C.M.v.Z., N.J.B.) and Neurology (R.J.W.), Johns Hopkins University School of Medicine, Baltimore, MD.

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FIG 1. Case 1: 67-year-old man with word-finding and comprehension difficulties imaged 4 hours (top row) and 4 days (bottom row) after symptom onset. The T2-weighted (T2W), diffusion-weighted (Isotropic DWI), and Dav images were all normal at 4 hours; but at 4 days, the T2-weighted image showed an area of infarction in the left parietal region (arrows).
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FIG 2. Case 2: 65 year-old man with mild to moderate aphasia, a slight left-sided facial droop, and minimal left pronator drift scanned 3.5 hours (top row), 13 hours (middle row), and 4 days (bottom row) after symptom onset.
Top row, Initial T2-weighted (T2W), diffusion-weighted (Isotropic DWI), and Dav images were normal, but the perfusion MR image revealed a large area of delayed flow in the right MCA territory.
Middle row, At 13 hours, the T2-weighted image remained normal but diffusion-weighted hyperintensity and reduced Dav are now apparent in the right MCA territory.
Bottom row, T2-weighted image at 4 days revealed hemorrhagic infarction with edema and mild mass effect. The infarct showed decreased Dav at this time, while the perilesional edema had increased Dav.
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