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AJNR - American Journal of Neuroradiology

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A Comparison of MR Imaging with Fast-FLAIR, HASTE-FLAIR, and EPI-FLAIR Sequences in the Assessment of Patients with Multiple Sclerosis

Massimo Filippi^a, Maria A. Rocca^a, Martin Wiessmann^a, Silvia Mennea^a, Mara Cercignani^a, Tarek A. Yousry^a, Maria P. Sormani^a and Giancarlo Comi^a

^a From the Neuroimaging Research (M.F., M.A.R., S.M., M.C., M.P.S.) and Clinical Trials (G.C.) Units, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy; and the Department of Neuroradiology, Klinikum Grosshadern, University of Munich, Germany (M.W., T.A.Y.).

View larger version (73K): [in a new window]   FIG 1. A–C, Axial fast-FLAIR (TR/TE/excitations = 9500/119/1, TI = 2200) (A), HASTE-FLAIR (TE/excitations = 87/1, TI = 2800) (B), and EPI-FLAIR (TE/excitations = 54/1, TI = 2200) (C) images of the brain in a patient with clinically definite MS. The same lesions are seen on all three images.

View larger version (76K): [in a new window]   FIG 2. A–C, Axial fast-FLAIR (TR/TE/excitations = 9500/119/1, TI = 2200) (A), HASTE-FLAIR (TE/excitations = 87/1, TI = 2800) (B), and EPI-FLAIR (TE/excitations = 54/1, TI = 2200) (C) images of the brain in a patient with clinically definite MS. A similar number of large lesions is seen on all three images. Compared with B and C, A shows more smaller lesions in the white matter of both cerebral hemispheres.

View larger version (117K): [in a new window]   FIG 3. A and B, Axial fast-FLAIR (TR/TE/excitations = 9500/119/1, TI = 2200) (A) and EPI-FLAIR (TE/excitations = 54/1, TI = 2200) (B) images of the brain in a patient with clinically definite MS. In A, two lesions are visible in the right cerebral peduncle and in the white matter of the right temporal lobe. In B, these lesions are not visible because of the presence of susceptibility artifacts.

View larger version (105K): [in a new window]   FIG 4. A–E, Axial EPI-FLAIR (TE/excitations = 54/1, TI = 2200) images of the brain in a patient with clinically definite MS in whom 10 (A), eight (B), six (C), four (D), and two (E) measurements were obtained. Multiple white matter lesions are visible on all images.