Advanced

AJNR - American Journal of Neuroradiology

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Patel, U. J. Articles by Kolson, D. Search for Related Content PubMed PubMed Citation Articles by Patel, U. J. Articles by Kolson, D.

Serial Analysis of Magnetization-Transfer Histograms and Expanded Disability Status Scale Scores in Patients with Relapsing-Remitting Multiple Sclerosis

Upen J. Patel^a, Robert I. Grossman^a, Michael D. Phillips^a, Jayaram K. Udupa^a, Joseph C. McGowan^a, Yukio Miki^a, Luogang Wei^a, Marcia Polansky^a, Mark A. van Buchem^a and Dennis Kolson^a

^a From the Department of Radiology, Florida Community Imaging Centers, Dunedin, FL (U.J.P.); the Departments of Radiology (R.I.G., M.D.P., J.K.U., J.C.McG., Y.M. L.W.) and Neurology (D.K.), Hospital of the University of Pennsylvania, Philadelphia; the Department of Radiology, Leiden University Hospital, the Netherlands (M.A.vB.); and the Division of Biometrics, Allegheny University Health System, Philadelphia (M.P.).

View larger version (10K): [in a new window]   FIG 1. Normalized MTR histogram from a single MR examination. MTR-HPH measures 0.083.

View larger version (9K): [in a new window]   FIG 2. Representative patient data show no significant change in EDSS score with time. Nevertheless, a significant decline in MTR-HPH is seen during the same period. Median absolute deviation linear regression was used to calculate slopes for changes in MTR-HPH and EDSS scores over time.

View larger version (11K): [in a new window]   FIG 3. Graph shows distribution of MTR-HPH slope (change in MTR-HPH per year) for an individual patient. The average slope for the study group was -0.005. A statistically significant number of patients with relapsing-remitting MS show a decline in MTR-HPH with time.