Advanced

AJNR - American Journal of Neuroradiology

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Moriarty, D. M. Articles by Jackson, A. Search for Related Content PubMed PubMed Citation Articles by Moriarty, D. M. Articles by Jackson, A.

Memory Dysfunction in Multiple Sclerosis Corresponds to Juxtacortical Lesion Load on Fast Fluid-Attenuated Inversion-Recovery MR Images

David Michael Moriarty^,a, Alison Jane Blackshaw^a, Paul Robert Talbot^a, Helen Louise Griffiths^a, Julie Sarah Snowden^a, Valerie Fern Hillier^a, Stephen Capener^a, Roger David Laitt^a and Alan Jackson^a

^a From the Division of Imaging Science and Biomedical Engineering, University of Manchester (D.M.M., V.F.H., S.C., A.J.); and the Departments of Neurology (Cerebral Function Unit) (A.J.B., P.R.T., H.L.G., J.S.S.) and Neuroradiology (R.D.L.), Manchester Royal Infirmary, UK.

View larger version (163K): [in a new window]   FIG 1. A–F, Matching lesions on proton density–weighted (A), T2-weighted CSE (C) and fast FLAIR (E) images. 1 denotes a population of lesions in the gray matter, extending to the juxtacortical boundary, which are evident on fast FLAIR but not on proton density—or T2-weighted CSE images. These lesions are further demonstrated on the magnified (x2) proton density–weighted (B) T2-weighted CSE (D), and fast FLAIR (F) images. 2 indicates a population of lesions that are less conspicuous on proton density–and T2-weighted CSE images (C). 3 relates to a medium-sized white matter lesion that is obvious on all imaging sequences.

View larger version (10K): [in a new window]   FIG 2. Bland and Altman plot shows the differences against mean for interobserver variation data.