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Appearance of Normal Brain Maturation on Fluid-Attenuated Inversion-Recovery (FLAIR) MR Images

Ryuichiro Ashikagaa, Yutaka Arakia, Yukihiko Onoa, Yasumasa Nishimuraa and Osamu Ishidaa

a From the Department of Radiology, Kinki University School of Medicine, 377–2, Ohno-higashi, Osakasayama, Osaka 589–8511, Japan.



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  		FIG 1. Age distribution of patients in study group, comprising 52 children ranging in age from 1 week to 4 years



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  		FIG 2. A–E, Grades of signal intensity on FLAIR images plotted against the patient's age for individual anatomic sites: posterior limb of internal capsule (A), cerebellar peduncle (B), frontal deep white matter (C), occipital deep white matter (D), and centrum semiovale (E). Diamonds represent the grade of each patient



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  		FIG 3. Brain MR images at the level of the internal capsule of a 1-week-old infant.

A, T1-weighted (500/15/2) image shows high signal intensity in the posterior limb of the internal capsule.

B, T2-weighted (4000/120/2) SE image shows low signal intensity in the posterior limb of the internal capsule.

C, FLAIR (8000/120/1, TI = 2000) image shows high signal intensity in the posterior limb of the internal capsule (arrows). The signal intensity of the gray and white matter is similar to that on T1-weighted images.



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  		FIG 4. Brain MR images of a 30-week-old infant.

A, T1-weighted (500/15/2) image shows high signal intensity in the posterior limb of the internal capsule. The occipital white matter shows high intensity, suggesting myelination.

B, T2-weighted (4000/120/2) SE image shows low signal intensity of the posterior limb of the internal capsule.

C, FLAIR (8000/120/1, TI = 2000) image shows decreased signal intensity the posterior limb of the internal capsule (arrows). The occipital white matter shows increased signal intensity.



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  		FIG 5. Brain MR images of a 34-month-old child.

A and B, T1-weighted (500/15/2) (A) and T2-weighted (4000/120/2) (B) SE images show the brain already has an adult pattern of signal intensity.

C, On this FLAIR (8000/120/1, TI = 2000) image, the myelinated areas show low signal intensity with time and become similar to that on the SE T2-weighted image.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X