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Neurocutaneous Melanosis Presenting with Intracranial Amelanotic Melanoma

Bart D. VanzieleghemGo,a, Marc M. Lemmerlinga and Rudy N. Van Costera

a From the Departments of Radiology (B.D.V., M.M.L.) and Pediatrics (R.N.V.C.), University Hospital Gent, Belgium.



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  		FIG 1. Multiple congenital hairy nevi are seen on a 6-month-old.

FIG 2. T1-weighted (500/12/2—repetition time/echo time/excitations) midsagittal image shows hydrocephalus with enlarged lateral, third, and fourth ventricles in a 14-month-old. Note the downward bending of the floor of the third ventricle (arrowheads).



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  		FIG 3. Follow-up MR examination of 2-year-old girl.

A, An unenhanced axial T1-weighted (500/12/3) image shows a hypointense lesion anterior and superior to the pons with invasion of the mesencephalon (black arrows).

B, Axial T2-weighted (3000/120/1) image shows the mass is isointense with surrounding edema (white arrows) relative to the cerebral cortex.

C, Note the strong enhancement after gadolinium administration.



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  		FIG 4. Routine hematoxylin and eosin staining is shown. The nuclei are prominent and have a finely distributed chromatin with a large nucleolus. Tumor cells have a clear cytoplasm, devoid of melanin pigment





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X