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Radiologic and Histopathologic Evaluation of Canine Artery Occlusion after Collagen-Coated Platinum Microcoil Delivery

Shinichi TamataniGo,a, Tsunenori Ozawaa, Takashi Minakawaa, Shigekazu Takeuchia, Tetsuo Koikea and Ryuichi Tanakaa

a From the Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.



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  		FIG 1. Scanning electron microscopic image of a collagen-coated platinum microcoil that was inserted into an internal maxillary canine artery via a Tracker 18 microcatheter (magnigication x430). Most of the coil surface was covered with a thin layer of collagen.

FIG 2. Graphic representation of angiographic findings of 18 canine arteries treated with one uncoated and one collagen-primed coil. Angiography was performed 30 minutes postoperatively, and either 1 or 3 days, 1, 2, 3, 4, 8, 12, or 16 weeks after embolization



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  		FIG 3. Scanning electron microscopic images of coils after embolization.

A, An uncoated platinum microcoil shows limited thrombic formation 30 minutes after delivery (magnification x350).

B, A collagen-coated platinum microcoil shows massive thrombic formation 30 minutes after delivery (magnification x310).

C, An uncoated platinum microcoil shows endothelial cells beginning to proliferate on the fibrous tissue formed on the coil within 1 week of embolization (magnification x200).

D, An uncoated platinum microcoil surface is completely covered with endothelial cells within 4 weeks of embolization. Organized tissue is seen under the endothelial cells (magnification x160).

E, A collagen-coated platinum microcoil surface is covered with endothelial cells within a week of embolization (magnification x280).

F, A collagen-coated platinum microcoil shows a typical mosaic pattern of flat, elongated, spindle-shaped endothelial cells throughout its surface 2 weeks after embolization (magnification x290).





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X