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99mTc-Bicisate and 99mTc-HMPAO SPECT Imaging in Early Spontaneous Reperfusion of Cerebral Embolism

Kuniaki OgasawaraGo,a, Kazuo Mizoia, Satoru Fujiwaraa and Takashi Yoshimotoa

a From the Department of Neurosurgery, Kohnan Hospital (K.O., S.F.), and the Department of Neurosurgery, Tohoku University School of Medicine (K.M., T.Y.), Japan.



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FIG 1. Case 1: 54-year-old man with atrial fibrillation and sudden onset of left-sided hemiparesis.

A, 99mTc-HMPAO SPECT image 4.5 hours after the onset of stroke shows hypoactivity in the right frontal and temporal lobes.

B, 99mTc-HMPAO SPECT image (left) obtained 12 hours after the initial study shows hyperactivity in the right temporal lobe; a 99mTc-ECD SPECT image (right) shows hypoactivity in the same area.

C, and D, CT scans after the SPECT study reveal a low-density area only in the right frontal lobe (C); 10 hours later, a partially hemorrhagic infarct has developed in the right temporal lobe (D).



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FIG 2. Case 2: 69-year-old man with atrial fibrillation and sudden onset of left-sided hemiparesis.

A, 99mTc-HMPAO SPECT image 7.5 hours after the onset of stroke shows hypoactivity in the right parietal lobe.

B, Both 99mTc-HMPAO (left) and 99mTc-ECD (right) SPECT images obtained 12 hours after the initial study depict hyperactivity in the right parietal lobe.

C, Follow-up CT scan does not show any abnormality.