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AJNR - American Journal of Neuroradiology

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Magnetization Transfer Ratio of White Matter Hyperintensities in Subcortical Ischemic Vascular Dementia

Jody L. Tanabe^a, Frank Ezekiel^a, William J. Jagust^a, Bruce R. Reed^a, David Norman^a, Norbert Schuff^a, Michael W. Weiner^a, Helena Chui^a and George Fein^,a

^a From the Department of Radiology, New York University Medical Center, New York (J.L.T.); Psychiatry Research (F.E., G.F.) and Magnetic Resonance Unit (N.S., M.W.W.), Department of Veterans Affairs Medical Center, San Francisco, CA; the Departments of Radiology (D.N., N.S., M.W.W.) and Psychiatry (M.W.W., G.F.), University of California, San Francisco; the Center for Functional Imaging, Lawrence Berkeley Laboratory (W.J.J.) and the Department of Neurology (W.J.J., B.R.R.), University of California, Davis; and the Department of Neurology, University of Southern California, Los Angeles (H.C.).

View larger version (219K): [in a new window]   FIG 1. A–C, A, Proton density–weighted section from a subject with extensive WMSH; B, corresponding segmentation section showing different tissue classes (WMSH in black); C, color-coded map of MTR of WMSH (green corresponds to lowest MTR and yellow to highest MTR, shown in the color bar); and D, a sample of periventricular WMSH (black line, defined as those pixels representing the overlap between WMSH and a two-pixel region grown of ventricular space but excluding all partial volumed pixels (see Methods for details)

View larger version (28K): [in a new window]   FIG 2. MTR of periventricular and nonperiventricular WMSH for control subjects and patients with SIVD. Values are mean ± 1 SD; P values are before correction of the percentage of WMSH

View larger version (21K): [in a new window]   FIG 3. The effect of group and percentage of WMSH on the MTR of periventricular WMSH. Control subjects indicated by filled circles, SIVD patients by open circles.

View larger version (38K): [in a new window]   FIG 4. Plot showing no correlation between lesion size and MTR of that lesion for either control subjects or patients with SIVD. Control subjects indicated by filled circles, SIVD patients by open circles.