AJDRAJNR - American Journal of Neuroradiology

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Adult-Onset Neurologic Dysfunction Associated with Cortical Malformations

Woo Ho Choa, David Seidenwurma and A. James BarkovichGo,a

a From the Department of Radiology, Neuroradiology Section, University of California, San Francisco.



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FIG 1. Patient 3. Diffuse subependymal heterotopia.

A, Sagittal spin-echo (550/15 [TR/TE]) image shows multiple ovoid subependymal nodules isointense to cortical gray matter, protruding into the lateral ventricle.

B, Axial spin-echo (2500/80) image shows that diffuse heterotopia, lining the lateral walls of the lateral ventricles, remain isointense to gray matter.

C, Midline sagittal spin-echo (550/15) image shows the diffusely thin body of the corpus callosum and a large posterior fossa cyst.



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FIG 2. Patient 7. Heterotopia involving the frontal horn. Axial spin-echo (2500/80) image shows subependymal heterotopia associated with the dilated left frontal horn.FIG 3. Patient 1. Contiguous subependymal heterotopia.

A, Axial spin-echo (2500/80) image shows multiple contiguous nodules lining the occipital homs and trigones.

B, Sagittal fast spin-echo (3500/102) image reveals the thin splenium.



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FIG 4. Single heterotopion. Axial spin-echo (2500/80) (A) and coronal 3D FT gradient-echo (35/7 [{theta} = 35°]) (B) images show that the single heterotopion is associated with deep infolding of the adjacent cortex (arrows).FIG 5. Patient 15. Closed-lip schizencephaly. Axial spin-echo (2500/30) image shows small closed-lip schizencephaly involving the left central fissure and decreased white matter volume of the ipsilateral hemisphere