Adult-Onset Neurologic Dysfunction Associated with Cortical Malformations
Woo Ho Choa,
David Seidenwurma and
A. James Barkovich
,a
a From the Department of Radiology, Neuroradiology Section, University of California, San Francisco.

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FIG 1. Patient 3. Diffuse subependymal heterotopia.
A, Sagittal spin-echo (550/15 [TR/TE]) image shows multiple ovoid subependymal nodules isointense to cortical gray matter, protruding into the lateral ventricle.
B, Axial spin-echo (2500/80) image shows that diffuse heterotopia, lining the lateral walls of the lateral ventricles, remain isointense to gray matter.
C, Midline sagittal spin-echo (550/15) image shows the diffusely thin body of the corpus callosum and a large posterior fossa cyst.
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FIG 2. Patient 7. Heterotopia involving the frontal horn. Axial spin-echo (2500/80) image shows subependymal heterotopia associated with the dilated left frontal horn.FIG 3. Patient 1. Contiguous subependymal heterotopia.
A, Axial spin-echo (2500/80) image shows multiple contiguous nodules lining the occipital homs and trigones.
B, Sagittal fast spin-echo (3500/102) image reveals the thin splenium.
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FIG 4. Single heterotopion. Axial spin-echo (2500/80) (A) and coronal 3D FT gradient-echo (35/7 [ = 35°]) (B) images show that the single heterotopion is associated with deep infolding of the adjacent cortex (arrows).FIG 5. Patient 15. Closed-lip schizencephaly. Axial spin-echo (2500/30) image shows small closed-lip schizencephaly involving the left central fissure and decreased white matter volume of the ipsilateral hemisphere
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