AJDRAJNR - American Journal of Neuroradiology

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Warmuth-Metz, M.
Right arrow Articles by Solymosi, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Warmuth-Metz, M.
Right arrow Articles by Solymosi, L.

Uncommon Morphologic Characteristics in Leigh's Disease

Monika Warmuth-MetzGo,a, E. Hofmanna, M. Büssea and L. Solymosia

a From the Department of Neuroradiology (M.W.-M., E.H., L.S.) and Pediatrics (M.B.), University of Würzburg, Würzburg, Germany.



View larger version (289K):

[in a new window]
  		FIG 1. 4-month-old male patient with severe developmental delay and elevated lactate in blood and CSF.

A, T2-weighted image showing striking hyperintensity in the periventricular frontal white matter and the caput of the dentate nuclei on both sides. Because of the swollen dentate nuclei, the frontal horns of the lateral ventricles are compressed.

B, Unenhanced, axial T1-weighted MR image obtained at the level of the third ventricle (same level as that shown in A). The third and lateral ventricles are compressed by the basal ganglia and thalami. Note the marked symmetrical hyperintensity of the frontal and less pronounced occipitoparietal white matter.

C, The same plane as that shown in B obtained after the injection of contrast medium. Although the striate bodies show dense symmetrical enhancement, the thalami take up contrast material only around the dorsal part of the third ventricle. There is also intensive enhancement of the white matter and the swollen mamillary bodies.

D, Midsagittal T1-weighted contrast-enhanced MR image. No abnormality is seen caudal to the plane of the inferior colliculi. Periaqueductal enhancement, as well as hypothalamic and mamillary body enhancement, is very dense.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X