Regional Cerebral Glucose Metabolism and Blood Flow in a Patient with Marchiafava-Bignami Disease
Kazunari Ishiia,
Yoshitaka Ikejiria,
Masahiro Sasakia,
Hajime Kitagakia and
Etsuro Moria
a From the Division of Neuroimaging Research (K.I., M.S., H.K.) and Clinical Neurosciences (Y.I., E.M.), Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan.
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FIG 1. Images of a 54-year-old man, with a history of heavy alcohol drinking for 30 years, who was referred because of speech and writing disturbance.
A, Sagittal T1-weighted MR image shows atrophy of entire corpus callosum, except for the splenium. Hypointense bands are seen in the genu and truncus of the corpus callosum.
B, Axial T2-weighted MR images show a hyperintense area in the corpus callosum, periventricular hyperintensity, and hyperintense areas in the frontal white matter.
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FIG 2. Whole-brain cerebral metabolic rate of glucose (CMRglc) is reduced diffusely and strongly in the frontal and parietal lobe and the thalamus. CMRglcs in the basal ganglia are preserved. The white matter lesions in the frontal lobes do not seem to influence the frontal CMRglc, because the frontal CMRglc is affected as severely as the parietal CMRglc.FIG 3. IMP CBF images show the same distributions of the affected area of CMRglc
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