A Longitudinal MR Study of the Presymptomatic Phase in a Patient with Clinically Definite Multiple Sclerosis
Giovanna Mastronardoa,
Maria A. Roccaa,
Giuseppe Iannuccia,
Clodoaldo Pereiraa and
Massimo Filippia
a From the Neuroimaging Research Unit (G.M., M.A.R., G.I., M.F.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Milan, Italy, and the Department of Neuroradiology (C.P.), Scientific Institute Ospedale San Raffaele, University of Milan, Milan, Italy.
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FIG 1. Axial brain MR images of a patient with CDMS, obtained before the onset of clinical symptoms. On the proton density–weighted image (A), many periventricular and discrete white matter lesions are visible. Two of them enhance on the contrast-enhanced T1-weighted image (B)
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FIG 2. MT histograms of a patient with CDMS, obtained before the onset of clinical symptoms (gray line), and MT histograms of 10 healthy control volunteers (black line)
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FIG 3. Coronal MR images of the spinal cord of a patient with CDMS, obtained before the onset of clinical symptoms. On the proton density–weighted image (A), a small lesion is visible in the posterior part of the cord at C2–C3. This lesion enhances on the contrast-enhanced T1-weighted image (B).FIG 4. Coronal T1-weighted MR image of the brain of a patient, obtained at the time of an acute optic neuritis when a diagnosis of CDMS was made. Enhancement is visible (arrow) in the intraorbital portion of the left optic nerve
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