MR Imaging Quantitation of Gray Matter Involvement in Multiple Sclerosis and Its Correlation with Disability Measures and Neurocognitive Testing
Isabelle Catalaaa,
Jennifer C. Fultona,
Xuang Zhanga,
Jayarm K. Udupaa,
Dennis Kolsona,
Murry Grossmana,
Lougang Weia,
Joseph C. McGowana,
Marcia Polanskya and
Robert I. Grossman
,a
a From the Departments of Radiology (I.C., J.C.F., X.Z., J.K.U., L.W., J.C.M., M.P., R.I.G.) and Neurology (D.K., M.G.), University of Pennsylvania Medical Center, Philadelphia, PA 19104.
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FIG 1. The second step of the choice and delineation of gray matter lesions. Example with the choice and delineation of a deep gray matter lesion.
A, The axial proton density–weighted image of one of the relapsing-remitting MS patients showing a right temporal lesion involving the white matter and both deep and cortical gray matter.
B, The same lesion as selected by the software, in green color, after going through the step 1 (removal of the normal parts, CSF, and sulci).
C, Manual removal of the white matter and cortical gray matter constituting the lesion.
D, The isolated deep gray matter part of the temporal lesion.
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FIG 2. Example demonstrating the selection of a deep gray matter lesion.
A, An axial proton density–weighted image of the brain of one of the relapsing-remitting MS patients, showing a left thalamic lesion.
B, The same lesion as it is selected by the software, in green color.
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FIG 3. Example demonstrating the choice of a cortical gray matter lesion.
A, An axial proton density–weighted image of one of the relapsing-remitting MS patients showing a right temporal cortical lesion.
B, The same lesion as selected by the software.
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