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AJNR - American Journal of Neuroradiology

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Proton MR Spectroscopy of Sjögren-Larsson's Syndrome

Toshiyuki Mano^a, Jiro Ono^a, Tatsuro Kaminaga^a, Katsumi Imai^a, Kosuke Sakurai^a, Koushi Harada^a, Toshisaburo Nagai^a, William B. Rizzo^a and Shintaro Okada^a

^a From the Department of Pediatrics (T.M., J.O., K.I., S.O.), Osaka University Medical School, the Department of Radiology (T.K.), Teikyo University medical School, the Department of Radiology (K.S.), Osaka Teisin Hospital, the Division of Radiology (K.H.), Kaizuka Municipal Hospital, the Department of Pediatrics (T.N.), Toyonaka Municipal Hospital, and the Departments of Pediatrics and Human Genetics (W.B.R.), Medical College of Virginia.

View larger version (44K): [in a new window]   FIG 1. T2-weighted MR imaging (A) (4000/90 [TR/TE]) and 1H-MRS (B) in the deep white matter of the frontal lobe in Patient 1. The volumes of interest are indicated by square boxes. The spectra using longer echo times (140 and 270 ms) also showed the extra peaks at 1.3 ppm (black arrow) and at 0.9 ppm (white arrow). Note.—Abbreviations: NAA, N-acetyl aspartate; PC, phosphocreatine; Cr, creatine; Cho, choline

View larger version (50K): [in a new window]   FIG 2. T2-weighted MR imaging (A) (4000/90) and 1H-MRS (B) in the deep white matter of the frontal lobe in Patient 2. 1H-MR spectra were similar to those shown in figure 1B