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Coexistent Holoprosencephaly and Chiari II Malformation

Nancy RollinsGo,a, Jeanne Joglara and Jeffery Perlmana

a From the Departments of Radiology (N.R., J.J.) and Pediatrics (J.P.), Children's Medical Center and the University of Texas Southwestern Medical School, Dallas, TX.



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  		FIG 1. MR images from a case of coexistent Chiari II malformation and holoprosencephaly that occurred in a viable infant.

A, Stigmata of the Chiari II malformation. Sagittal T1-weighted MR image shows elongated caudally displaced effaced fourth ventricle and caudal herniation of the cerebellum.

B, Manifestations of holoprosencephaly. Axial T1-weighted MR image shows absent interhemispheric falx and partial fusion of frontal cortex and white matter.

C, Follow-up image obtained at 13 months of age. Sagittal T1-weighted MR image shows poor myelination and extensive polymicrogyria along the mesial surfaces of the cerebral hemispheres. Arrow indicates the large massa intermedia.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X