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Gender Effects on Age-Related Changes in Brain Structure

Jiang XuGo,a, Shotai Kobayashia, Shuhei Yamaguchia, Ken-ichi Iijimaa, Kazunori Okadaa and Kazuya Yamashitaa

a From the Department of Internal Medicine III (J.X., S.K., S.Y., K-I.I., K.O., K.Y.), Shimane Medical University, Izumo, Japan; and the Shimane Institute of Health Science (S.K.), Izumo, Japan.



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FIG 1. T1-weighted MR slices (350/15/7 [TR/TE/excitations]) used for definition of regions of interest.

A, F2, upper frontal lobes; F1, lower frontal lobes.

B, F4, upper frontal lobes; F3, lower frontal lobes; T1, temporal lobe.

C, F5, posterior parts of frontal lobe; B-G, basal ganglia; T2, middle part of temporal lobe.

D, P, parietal lobe; Tha, thalamus; T3, posterior part of temporal lobe.

E, P-O, parieto-occipital lobe; Ce, cerebellum.

F, Midline sagittal cross-sectional area of cranial cavity.



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FIG 2. Gender differences in brain atrophy with aging in posterior part of right frontal lobes between young and old groups