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AJNR - American Journal of Neuroradiology

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Dementia, Quantitative Neuroimaging, and Apolipoprotein E Genotype

Erin D. Bigler^,a, Christopher M. Lowry^a, Carol V. Anderson^a, Sterling C. Johnson^a, John Terry^a and Marc Steed^a

^a From the Department of Psychology and Neuroscience, 1001 SWKT, Brigham Young University, Provo, UT 84602. Address reprint requests to Erin D. Bigler, PhD.

View larger version (23K): [in a new window]   FIG 1. A–C, Graphic depictions of mean (± SD) for brain volume (A), hippocampal volume (B), and VBR (C) for 4+ and 4- subjects for each diagnostic classification: control group, Alzheimer disease (AD), mild ambiguous (M/A), vascular dementia (VaD), cerebrovascular disease (CVA), frontal lobe dementia (FLA), Parkinson's disease (Parkinson), psychiatric disorder (Psych), dementia unknown (Dem Unk), alcoholism (ETOH), and amnesic disorder (Mem Amn). The first numeric value represents the total number of 4- subjects, with the second numeric value indicating sample size of the 4+ subjects

View larger version (25K): [in a new window]   FIG 2. A–C, Scatter plots for subjects with AD and combined MCI and VaD by age for brain volume (A), hippocampal volume (B), and VBR (C) based on the following correlations: Brain volume, r4- = -.26, P .01; r4+ = -0.19, P .01; hippocampal volume, r4- = 0.17, P .05; r4+ = 0.01, P > .05; and VBR, r4- = -.34, P .01; r4+ = 0.13, P .05

View larger version (20K): [in a new window]   FIG 3. A–C, Mean (± SD) for brain volume (A), hippocampal volume (B), and VBR (C) by length of disease (LOD) in years

View larger version (17K): [in a new window]   FIG 4. A–C, Mean (± SD) for brain volume (A), hippocampal volume (B), and VBR (C) for 3MS performance, which has been segregated into three levels: normal (> 91), mild to moderate impairment (71–90), and moderate to severe impairment (<70). Correlation values (Spearman rank) for each brain measure by 3MS performance level are shown in the boxes