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AJNR - American Journal of Neuroradiology

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Echomorphologic and Histopathologic Characteristics of Unstable Carotid Plaques

Thomas J. Tegos^a,b, Muhammed Sohail^a, Michael M. Sabetai^a, Peter Robless^a, Nuzhat Akbar^a, Gary Pare^a, Gerard Stansby^a and Andrew N. Nicolaides^a

^a From the Irvine Laboratory for Cardiovascular Investigation and Research, Department of Vascular Surgery (T.J.T., M.M.S., P.R., G.P., G.S., A.N.N.), St Mary's Hospital, Imperial College of Science, Technology and Medicine; the Department of Histopathology (M.S.), King's College Hospital; and the Department of Histopathology (N.A.), St Bartholomew's Hospital, London, UK.
^b Address reprint requests to Dr T. J. Tegos, Irvine Laboratory, 10th floor, QEQM, St Mary's Hospital, Praed St, London, W2 1NY, UK.

View larger version (71K): [in a new window]   FIG 1. Hypoechoic (echolucent) plaque (GSM = 0).FIG 2. Hyperechoic (echogenic) plaque (GSM = 28).FIG 3. Normalized image of a carotid plaque (GSM = 25)

View larger version (106K): [in a new window]   FIG 4. Microscopic appearance of a carotid plaque with necrotic core and calcification (H&E stain)

View larger version (10K): [in a new window]   FIG 5. Correlation of sonographic (longitudinal) and histologic (transverse) plaque area (Pearson's correlation, P = .001, r = 0.386).FIG 6. Correlation of GSM and relative necrotic core size (Pearson's correlation, P = 0.37, r = -0.1)