Magnetoencephalography in Children with Landau-Kleffner Syndrome and Acquired Epileptic Aphasia
David F. Sobel
,a,
Maung Aunga,
Hiroshi Otsuboa and
Michael C. Smitha
a From the Divisions of Neuroradiology (D.F.S.) and Neurology (M.A.), Scripps Clinic, La Jolla, CA; the Division of Neurology (H.O.), The Hospital for Sick Children, Toronto, Canada; and the Epilepsy Center (M.C.S.), Department of Neurological Science, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL.
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FIG 1. Images from the case of a 6-year-old male patient.
A, Sagittal T1-weighted image from the right hemisphere shows perisylvian clustering of spike activity in the posterosuperior temporal gyrus or Wernicke's area.
B, Sagittal T1-weighted image from the left hemisphere shows perisylvian clustering of spike activity in the posterosuperior temporal gyrus or Wernicke's area.
C, Coronal T2-weighted image shows bilateral perisylvian clustering of spike activity in the posterosuperior temporal gyrus or Wernicke's area.
D, Six-second data epoch shows MEG wave forms from the left hemisphere above, right hemisphere below, and concurrent EEG in the middle. Numerous spikes are present bilaterally.
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FIG 2. Image from the case of a 10-year-old female patient. Sagittal T1-weighted image shows unilateral clustering of spike activity in the left posterotemporal lobe, with spikes bordering the posterior aspect of the left sylvian fissure
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