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AJNR - American Journal of Neuroradiology

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Nodal Volume Reduction after Concurrent Chemo- and Radiotherapy: Correlation between Initial CT and Histopathologic Findings

Robert F. Labadie^,a, Wendell G. Yarbrough^a, Mark C. Weissler^a, Harold C. Pillsbury^a and Suresh K. Mukherji^a

^a From the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.

View larger version (123K): [in a new window]   FIG 1. Representative CT scans (pretreatment [A]; post-treatment [B]) show the response to chemoradiation of a pathologically abnormal node (open arrow) and a normal node (closed arrow). The pathologically abnormal node shows a volume reduction of 84%, and the normal node shows a volume reduction of 98%. The extracapsular spread seen in the pathologically abnormal node in the pretreatment scan is not seen in the post-treatment scan

View larger version (45K): [in a new window]   FIG 2. Volume reduction of lymph nodes in response to chemoradiation. A, A significant (P < .01) volume reduction of 91 ± 4% is seen for the pathologically abnormal nodes. B, Volume reduction in the normal nodes, 55 ± 21%, is not significant (P > .1). Note the different scales between the panels

View larger version (115K): [in a new window]   FIG 3. Histopathologic findings of resected lymph nodes. A, Eighteen of 19 previously clinically positive lymph nodes show fibrosis and inflammation (original magnification, x20). B, In the other node (one of 19), a small focus of squamous cell carcinoma is apparent (arrows) (original magnification, x20).