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AJNR - American Journal of Neuroradiology

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The Effect of Contrast Material on Transcranial Doppler Evaluation of Normal Middle Cerebral Artery Peak Systolic Velocity

Haleem G. Khan^a, Philippe Gailloud^a, Ronald O. Bude^a, Jean-Baptiste Martin^a, Kazimierz T. Szopinski^a, Christophe Khaw^a, Daniel A. Rüfenacht^a and Kieran J. Murphy^,a

^a From the Division of Diagnostic and Interventional Radiology (H.G.K, P.G., J.-B.M, C.K., D.A.R., K.J.M.), Geneva University Hospital, Geneva, Switzerland; the Department of Radiology (R.O.B.), Ann Arbor, MI; and the Department of Radiology and Radiological Sciences (P.G., K.T.S., K.J.M.), Johns Hopkins Hospital, Baltimore, MD.

View larger version (56K): [in a new window]   FIG 1. Plot of mean normalized PSV for the aggregate patient data as a function of time. Time "zero" on the horizontal axis denotes baseline PSV before the administration of contrast material. Vertical lines at data points are error bars denoting ± 1 SD. Note that the mean PSV increases fairly rapidly, reaching a maximum within approximately 1 min of injection. Mean PSV remains elevated to approximately 5% above baseline until approximately 4 min after injection. FIG 2. Representative waveforms at the onset of contrast effect and at peak enhancement. Note the marked enhancement of the Doppler spectrum after the administration of contrast material and the apparent increase in PSV after the administration of contrast material compared with before

View larger version (126K): [in a new window]   FIG 3. Representative waveforms showing tapering velocities corresponding to a decrease of contrast effect are shown